Gayle began her acting career as Baby Jane in the off-Boardway production of Gypsy. She then reprised her role when the production transfered into Boardway a few months later. She then later co-starred in the off-Boardway play Oohrah! at the Alantic Threate Company and the MCC Theatre Family Week. Gayle also was featured in the 2007 Broadway production of Dr Seuss' How the Grinch Stole Christmas! The Musical.
She was well known in her televsion show Blue Bloods, but also in the USA'S Royal Pains where she was a guest star. She then appeared in the CBS soap opera As the World Turns where she was a recurring character.
In her film career she co-stars in Detachment which was released in 2012. In 2012 also co-stars in the film Stolen as Nicholas Cage's daughter and the film Congress it was released in 2013.